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Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster.

ABSTRACT: Polyoxins consist of 14 structurally variable components which differentiate at three branch sites of the carbon skeleton. Open reading frame (ORF) SAV_4805 of Streptomyces avermitilis, showing similarity to thymine-7-hydroxylase, was proved to enhance the diversity of polyoxins at the C-5 site of the 1-(5'-amino-5'-deoxy-?-d-allofuranuronosyl) pyrimidine moiety.

SUBMITTER: Zhao C

PROVIDER: S-EPMC2976252 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster.

Zhao Changming C Huang Tingting T Chen Wenqing W Deng Zixin Z

Applied and environmental microbiology 20100903 21

Polyoxins consist of 14 structurally variable components which differentiate at three branch sites of the carbon skeleton. Open reading frame (ORF) SAV_4805 of Streptomyces avermitilis, showing similarity to thymine-7-hydroxylase, was proved to enhance the diversity of polyoxins at the C-5 site of the 1-(5'-amino-5'-deoxy-β-d-allofuranuronosyl) pyrimidine moiety. ...[more]

PMID: 20817795

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