Ontology highlight
ABSTRACT:
SUBMITTER: Tran TH
PROVIDER: S-EPMC2976281 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Tran Thu H TH Jarrell Andrew A Zentner Gabriel E GE Welsh Adrienne A Brownell Isaac I Scacheri Peter C PC Atit Radhika R
Development (Cambridge, England) 20101027 23
Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, we show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. We show that Wnt signaling/β-catenin is absolutely required and sufficient for Dermo1 expression and dermal cell ident ...[more]