Ontology highlight
ABSTRACT:
SUBMITTER: Synnott JM
PROVIDER: S-EPMC2976306 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Synnott John M JM Guida Alessandro A Mulhern-Haughey Siobhan S Higgins Desmond G DG Butler Geraldine G
Eukaryotic cell 20100924 11
The regulation of the response of Candida albicans to hypoxic (low-oxygen) conditions is poorly understood. We used microarray and other transcriptional analyses to investigate the role of the Upc2 and Bcr1 transcription factors in controlling expression of genes involved in cell wall metabolism, ergosterol synthesis, and glycolysis during adaptation to hypoxia. Hypoxic induction of the ergosterol pathway is mimicked by treatment with sterol-lowering drugs (ketoconazole) and requires UPC2. Expre ...[more]