Ontology highlight
ABSTRACT:
SUBMITTER: Shafrir Y
PROVIDER: S-EPMC2976788 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Shafrir Yinon Y Durell Stewart R SR Anishkin Andriy A Guy H Robert HR
Proteins 20101201 16
Both soluble and membrane-bound prefibrillar assemblies of Abeta (Aβ) peptides have been associated with Alzheimer's disease (AD). The size and nature of these assemblies vary greatly and are affected by many factors. Here, we present models of soluble hexameric assemblies of Aβ42 and suggest how they can lead to larger assemblies and eventually to fibrils. The common element in most of these assemblies is a six-stranded β-barrel formed by the last third of Aβ42, which is composed of hydrophobic ...[more]