Ontology highlight
ABSTRACT:
SUBMITTER: Alushin GM
PROVIDER: S-EPMC2976827 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Alushin Gregory M GM Jane David D Mayer Mark L ML
Neuropharmacology 20100615 1
The availability of crystal structures for the ligand binding domains of ionotropic glutamate receptors, combined with their key role in synaptic function in the normal and diseased brain, offers a unique selection of targets for pharmaceutical research compared to other drug targets for which the atomic structure of the ligand binding site is not known. Currently only a few antagonist structures have been solved, and these reveal ligand specific conformational changes that hinder rational drug ...[more]