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1-Cyclo-propyl-6-fluoro-7-(4-nitro-so-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.

ABSTRACT: The title compound, C(17)H(17)FN(4)O(4), is a derivative of ciprofloxacin [1-cyclo-propyl-6-fluoro-4-oxo-7-(1-piperazin-yl)-1,4-dihydro-quinoline-3-carboxylic acid]. The crystal packing is stabilized by inter-molecular C-H?O hydrogen bonds together with ?-? electron ring inter-actions [centroid-centroid separations between quinoline rings of 3.5864?(11) and 3.9339?(13)?Å]. A strong intra-molecular O-H?O hydrogen bonds is present as well as an intra-molecular C-H?F inter-action.

SUBMITTER: Li T

PROVIDER: S-EPMC2977261 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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1-Cyclo-propyl-6-fluoro-7-(4-nitro-so-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid.

Li Tao T Tang Li-Rong LR Zeng Qiao-Ling QL Chen Wei-Jin WJ Huang Biao B

Acta crystallographica. Section E, Structure reports online 20090731 Pt 8

The title compound, C(17)H(17)FN(4)O(4), is a derivative of ciprofloxacin [1-cyclo-propyl-6-fluoro-4-oxo-7-(1-piperazin-yl)-1,4-dihydro-quinoline-3-carboxylic acid]. The crystal packing is stabilized by inter-molecular C-H⋯O hydrogen bonds together with π-π electron ring inter-actions [centroid-centroid separations between quinoline rings of 3.5864 (11) and 3.9339 (13) Å]. A strong intra-molecular O-H⋯O hydrogen bonds is present as well as an intra-molecular C-H⋯F inter-action. ...[more]

PMID: 21583715

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Ethyl 7-chloro-1-cyclo-propyl-6-fluoro-8-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate.

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Ethyl 1-cyclo-propyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate.

Project description:In the title compound, C(16)H(15)F(2)NO(4), the dihedral angle between the three-membered ring and the quinoline ring system is 64.3 (3)°. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link the mol-ecules, forming a column running along [101].

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