Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.
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ABSTRACT:
SUBMITTER: Kristiansen H
PROVIDER: S-EPMC2977878 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.
Kristiansen Helle H Scherer Christina A CA McVean Maralee M Iadonato Shawn P SP Vends Susanne S Thavachelvam Karthiga K Steffensen Thomas B TB Horan Kristy A KA Kuri Thomas T Weber Friedemann F Paludan Søren R SR Hartmann Rune R
Journal of virology 20100915 22
The 2'-5' oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatitis C patients and their clinical prognosis. Here we demonstrate that extracellular OAS1 enters into cells and possesses a strong antiviral activity, both in vitro and in vivo, which is independent of RNase L. The OAS protein directly inhibits viral prolif ...[more]
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