Ontology highlight
ABSTRACT:
SUBMITTER: Horton DL
PROVIDER: S-EPMC2977894 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Horton D L DL McElhinney L M LM Marston D A DA Wood J L N JL Russell C A CA Lewis N N Kuzmin I V IV Fouchier R A M RA Osterhaus A D M E AD Fooks A R AR Smith D J DJ
Journal of virology 20100908 22
All lyssaviruses cause fatal encephalitis in mammals. There is sufficient antigenic variation within the genus to cause variable vaccine efficacy, but this variation is difficult to characterize quantitatively: sequence analysis cannot yet provide detailed antigenic information, and antigenic neutralization data have been refractory to high-resolution robust interpretation. Here, we address these issues by using state-of-the-art antigenic analyses to generate a high-resolution antigenic map of a ...[more]