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ABSTRACT: Objective
Spindles are rhythmic bursts of 10-16 Hz activity, lasting ∼1 s, occur during normal stage 2 sleep. Spindles are slower in frontal EEG and possibly MEG. The posterior-fast EEG pattern may predominate early in the spindle, and the anterior-slow pattern late. We aimed to determine the proportion of spindles showing this spatio-spectro-temporal interaction for EEG, and whether it occurs in MEG.Methods
We recorded high density EEG and MEG from seven healthy subjects during normal stage 2 sleep. High vs. low frequency (12 vs. 14 Hz) power was measured early vs. late (25th-45th vs. 55th-75th duration percentile) in 183 spindle discharges.Results
The predicted spatio-spectro-temporal interaction was shown by 48% of EEG and 34% of MEG spindles (chance=25%). Topographically, high frequency EEG power was greatest at midline central contacts, and low frequency power at midline frontal. This frequency-specific topography was fixed over the course of the spindle.Conclusions
An evolution from posterior-fast to anterior-slow generators commonly occurs during spindles, and this is visible with EEG and to a lesser extent, MEG.Significance
The spatio-spectral-temporal evolution of spindles may reflect their possible involvement in coordinating cortical activity during consolidation.
SUBMITTER: Dehghani N
PROVIDER: S-EPMC2978261 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Dehghani Nima N Cash Sydney S SS Halgren Eric E
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20100715 2
<h4>Objective</h4>Spindles are rhythmic bursts of 10-16 Hz activity, lasting ∼1 s, occur during normal stage 2 sleep. Spindles are slower in frontal EEG and possibly MEG. The posterior-fast EEG pattern may predominate early in the spindle, and the anterior-slow pattern late. We aimed to determine the proportion of spindles showing this spatio-spectro-temporal interaction for EEG, and whether it occurs in MEG.<h4>Methods</h4>We recorded high density EEG and MEG from seven healthy subjects during ...[more]