Ontology highlight
ABSTRACT:
SUBMITTER: Cohen SM
PROVIDER: S-EPMC2978342 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cohen Stephanie M SM Chastain Paul D PD Rosson Gary B GB Groh Beezly S BS Weissman Bernard E BE Kaufman David G DG Bultman Scott J SJ
Nucleic acids research 20100622 20
For DNA replication to occur, chromatin must be remodeled. Yet, we know very little about which proteins alter nucleosome occupancy at origins and replication forks and for what aspects of replication they are required. Here, we demonstrate that the BRG1 catalytic subunit of mammalian SWI/SNF-related complexes co-localizes with origin recognition complexes, GINS complexes, and proliferating cell nuclear antigen at sites of DNA replication on extended chromatin fibers. The specific pattern of BRG ...[more]