Ethenzamide-gentisic acid-acetic acid (2/1/1).

ABSTRACT: In the title co-crystal solvate, 2-ethoxy-benzamide-2,5-dihydroxy-benzoic acid-ethanoic acid (2/1/1), 2C(9)H(11)NO(2)·C(7)H(6)O(4)·C(2)H(4)O(2), two nonsteroidal anti-inflammatory drugs, ethenzamide (systematic name: 2-ethoxy-benzamide) and gentisic acid (systematic name: 2,5-dihydroxy-benzoic acid), together with acetic acid (systematic name: ethanoic acid) form a four-component mol-ecular assembly held together by N-H?O and O-H?O hydrogen bonds. This assembly features two symmetry-independent mol-ecules of ethenzamide, forming supra-molecular acid-amide heterosynthons with gentisic acid and acetic acid. These heterosynthons involve quite strong O-H?O [O?O = 2.5446?(15) and 2.5327?(15)?Å] and less strong N-H?O [N?O = 2.9550?(17) and 2.9542?(17)?Å] hydrogen bonds. The overall crystal packing features several C-H?O and ?-? stacking inter-actions [centroid-centroid distance = 3.7792?(11)?Å].

SUBMITTER: Aitipamula S 

PROVIDER: S-EPMC2979229 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature