Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD.
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ABSTRACT:
SUBMITTER: Viejo-Borbolla A
PROVIDER: S-EPMC2979317 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD.
Viejo-Borbolla A A Martin A P AP Muniz L R LR Shang L L Marchesi F F Thirunarayanan N N Harpaz N N Garcia R A RA Apostolaki M M Furtado G C GC Mayer L L Kollias G G Alcami A A Lira S A SA
Mucosal immunology 20100721 6
Tumor necrosis factor α (TNFα) is a key pathogenic factor in Crohn's disease and rheumatoid arthritis. TNF(ΔARE) mice express high levels of TNFα and present Crohn's-like ileitis and arthritis. Alterations in the chemokine network could underline the TNF-driven ileitis. The aim of this study was to evaluate the role of TNF and chemokines in ileitis using ectromelia virus cytokine response modifier D (CrmD), a protein that binds TNFα and a limited number of chemokines. We generated transgenic mic ...[more]
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