Ontology highlight
ABSTRACT:
SUBMITTER: Tsvetkov PO
PROVIDER: S-EPMC2980701 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Biophysical journal 20101101 10
Zinc-induced aggregation of amyloid-β peptide (Aβ) is a hallmark molecular feature of Alzheimer's disease. Here we provide direct thermodynamic evidence that elucidates the role of the Aβ region 6-14 as the minimal Zn(2+) binding site wherein the ion is coordinated by His(6), Glu(11), His(13), and His(14). With the help of isothermal titration calorimetry and quantum mechanics/molecular mechanics simulations, the region 11-14 was determined as the primary zinc recognition site and considered an ...[more]