Ontology highlight
ABSTRACT:
SUBMITTER: Poirier CC
PROVIDER: S-EPMC2980710 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Poirier Christopher C CC Zheng Yixian Y Iglesias Pablo A PA
Biophysical journal 20101101 10
During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown. To search for a mechanism by which the presence of a mitotic membrane might help spindle morphology, we built a computational model that explores the interactions between these components. We show that an ...[more]