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Mitotic membrane helps to focus and stabilize the mitotic spindle.

ABSTRACT: During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown. To search for a mechanism by which the presence of a mitotic membrane might help spindle morphology, we built a computational model that explores the interactions between these components. We show that an elastic membrane around the mitotic apparatus helps to focus MT minus ends and provides a resistive force that acts antagonistically to plus-end-directed MT motors such as Eg5.

SUBMITTER: Poirier CC

PROVIDER: S-EPMC2980710 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Mitotic membrane helps to focus and stabilize the mitotic spindle.

Poirier Christopher C CC Zheng Yixian Y Iglesias Pablo A PA

Biophysical journal 20101101 10

During mitosis, microtubules (MTs), aided by motors and associated proteins, assemble into a mitotic spindle. Recent evidence supports the notion that a membranous spindle matrix aids spindle formation; however, the mechanisms by which the matrix may contribute to spindle assembly are unknown. To search for a mechanism by which the presence of a mitotic membrane might help spindle morphology, we built a computational model that explores the interactions between these components. We show that an ...[more]

PMID: 21081065

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