Unknown

Dataset Information

0

Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

ABSTRACT: African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7.3 (95% CI 5.6 to 9.5)}. The two APOL1 variants are common in African chromosomes but absent from European chromosomes, and both reside within haplotypes that harbor signatures of positive selection. ApoL1 (apolipoprotein L-1) is a serum factor that lyses trypanosomes. In vitro assays revealed that only the kidney disease-associated ApoL1 variants lysed Trypanosoma brucei rhodesiense. We speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans.

SUBMITTER: Genovese G 

PROVIDER: S-EPMC2980843 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7.3 (95% CI 5.6 to 9.5)}. The two APOL1 variants are common in African chromosomes but absent from  ...[more]

Similar Datasets

Unknown APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans.
| S-EPMC4448293 | biostudies-literature
Unknown APOL1 variants associate with increased risk of CKD among African Americans.
| S-EPMC3752955 | biostudies-literature
Unknown Association of preeclampsia with infant APOL1 genotype in African Americans.
| S-EPMC7238556 | biostudies-literature
Unknown Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.
| S-EPMC6109415 | biostudies-literature
Unknown Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans.
| S-EPMC3116917 | biostudies-literature
Unknown The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease.
| S-EPMC4022720 | biostudies-literature
Unknown Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans.
| S-EPMC5053912 | biostudies-literature
Unknown The MYH9/APOL1 region and chronic kidney disease in European-Americans.
| S-EPMC3098737 | biostudies-literature
Unknown Lack of Association of the APOL1 G3 Haplotype in African Americans with ESRD.
| S-EPMC4413768 | biostudies-literature
Unknown APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.
| S-EPMC4805128 | biostudies-literature