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ABSTRACT:
SUBMITTER: Crane CM
PROVIDER: S-EPMC2981068 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Crane Christine M CM Pierce Joshua G JG Leung Siegfried S F SS Tirado-Rives Julian J Jorgensen William L WL Boger Dale L DL
Journal of medicinal chemistry 20101001 19
A select series of methyl ether derivatives of vancomcyin aglycon were prepared and examined for antimicrobial activity against vancomycin-sensitive Staphylococcus aureus and vancomycin-resistant Enterococci faecalis as well as their binding affinity for D-Ala-D-Ala and D-Ala-D-Lac. The intent of the study was to elucidate the role selected key methyl groups may play in the improvement of the in vitro antimicrobial profile of the tetra methyl ether derivative of vancomycin aglycon against vancom ...[more]