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Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.

ABSTRACT: Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S. clavuligerus NRRL 3585 strain was produced by employing a hybrid approach that involved Sanger sequencing, Roche/454 pyrosequencing, optical mapping, and partial finishing. Its genome, comprising four linear replicons, one chromosome, and four plasmids, carries numerous sets of genes involved in the biosynthesis of secondary metabolites, including a variety of antibiotics.

SUBMITTER: Song JY 

PROVIDER: S-EPMC2981214 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.

Song Ju Yeon JY   Jeong Haeyoung H   Yu Dong Su DS   Fischbach Michael A MA   Park Hong-Seog HS   Kim Jae Jong JJ   Seo Jeong-Sun JS   Jensen Susan E SE   Oh Tae Kwang TK   Lee Kye Joon KJ   Kim Jihyun F JF  

Journal of bacteriology 20101001 23

Streptomyces clavuligerus is an important industrial strain that produces a number of antibiotics, including clavulanic acid and cephamycin C. A high-quality draft genome sequence of the S. clavuligerus NRRL 3585 strain was produced by employing a hybrid approach that involved Sanger sequencing, Roche/454 pyrosequencing, optical mapping, and partial finishing. Its genome, comprising four linear replicons, one chromosome, and four plasmids, carries numerous sets of genes involved in the biosynthe  ...[more]

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