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Caspofungin affects growth of Paracoccidioides brasiliensis in both morphological phases.

ABSTRACT: Five Paracoccidioides brasiliensis isolates were grown in the presence of caspofungin (0 to 1 ?g/ml). Inhibition of the yeast phase ranged from 20 to 65%, while in the mycelial form it ranged from 75% to 82%. Such variability was loosely related to the amount of cell wall ?-1,3-glucan. No association with point mutations in the ?-1,3-glucan synthase was detected. Caspofungin induced physical changes and cytoplasmic deterioration in both fungal phases.

SUBMITTER: Rodriguez-Brito S

PROVIDER: S-EPMC2981295 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Caspofungin affects growth of Paracoccidioides brasiliensis in both morphological phases.

Rodríguez-Brito Sabrina S Niño-Vega Gustavo G San-Blas Gioconda G

Antimicrobial agents and chemotherapy 20101011 12

Five Paracoccidioides brasiliensis isolates were grown in the presence of caspofungin (0 to 1 μg/ml). Inhibition of the yeast phase ranged from 20 to 65%, while in the mycelial form it ranged from 75% to 82%. Such variability was loosely related to the amount of cell wall β-1,3-glucan. No association with point mutations in the β-1,3-glucan synthase was detected. Caspofungin induced physical changes and cytoplasmic deterioration in both fungal phases. ...[more]

PMID: 20937789

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