Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC2981364 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Zhou Yu Y Xia Xiaoming X Lingle Christopher J CJ
Molecular pharmacology 20100820 5
Silver has been widely used in various medical products because of its antibacterial properties. However, there is only limited information concerning silver-related cytotoxicity. In this study we show that Ag(+) at low nanomolar concentrations (<10 nM) strongly inhibits the activity of large-conductance Ca(2+)-activated K(+) channels (BK) (Slo1), a widely expressed and physiologically important potassium channel. The Ag(+) inhibition is caused by irreversible modification on cytosolically acces ...[more]