Ontology highlight
ABSTRACT:
SUBMITTER: Ragas X
PROVIDER: S-EPMC2981434 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Ragàs Xavier X Sánchez-García David D Ruiz-González Rubén R Dai Tianhong T Agut Montserrat M Hamblin Michael R MR Nonell Santi S
Journal of medicinal chemistry 20101101 21
Structures of typical photosensitizers used in antimicrobial photodynamic therapy are based on porphyrins, phthalocyanines, and phenothiazinium salts, with cationic charges at physiological pH values. However, derivatives of the porphycene macrocycle (a structural isomer of porphyrin) have barely been investigated as antimicrobial agents. Therefore, we report the synthesis of the first tricationic water-soluble porphycene and its basic photochemical properties. We successfully tested it for in v ...[more]