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Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

ABSTRACT: Four hapalindole-related alkaloids, namely fischambiguines A and B, ambiguine P, ambiguine Q nitrile as well as ambiguine G nitrile were identified from the cultured cyanobacterium Fischerella ambigua (UTEX 1903). The structures were determined by spectroscopic analysis including MS, 1D and 2D NMR and X-ray crystallography. The alkaloids possessed fused pentacyclic and hexacyclic carbon skeletons. Fischambiguine B displayed a strong inhibitory activity against Mycobacterium tuberculosis with an MIC value of 2 ?M, with no detectable cytotoxicity in a Vero cell line.

SUBMITTER: Mo S

PROVIDER: S-EPMC2981615 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

Mo Shunyan S Krunic Aleksej A Santarsiero Bernard D BD Franzblau Scott G SG Orjala Jimmy J

Phytochemistry 20101019 17-18

Four hapalindole-related alkaloids, namely fischambiguines A and B, ambiguine P, ambiguine Q nitrile as well as ambiguine G nitrile were identified from the cultured cyanobacterium Fischerella ambigua (UTEX 1903). The structures were determined by spectroscopic analysis including MS, 1D and 2D NMR and X-ray crystallography. The alkaloids possessed fused pentacyclic and hexacyclic carbon skeletons. Fischambiguine B displayed a strong inhibitory activity against Mycobacterium tuberculosis with an ...[more]

PMID: 20965528

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