Memantine for AIDS dementia complex: open-label report of ACTG 301.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC2981797 | biostudies-literature | 2010 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Memantine for AIDS dementia complex: open-label report of ACTG 301.
Zhao Yu Y Navia Bradford A BA Marra Christina M CM Singer Elyse J EJ Chang Linda L Berger Joseph J Ellis Ronald J RJ Kolson Dennis L DL Simpson David D Miller Eric N EN Lipton Stuart A SA Evans Scott R SR Schifitto Giovanni G
HIV clinical trials 20100101 1
<h4>Objective</h4>To evaluate the long-term safety and efficacy of memantine use as treatment of HIV-associated cognitive impairment.<h4>Background</h4>The results of a 20-week, randomized, double-blind, placebo-controlled trial of memantine in HIV-infected participants with cognitive impairment (ACTG 301) were previously reported. We report the results of the up-to-60-week open-label phase following the double-blind phase.<h4>Method</h4>Participants received open-label memantine and were escala ...[more]
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