Ontology highlight
ABSTRACT:
SUBMITTER: Dudek SM
PROVIDER: S-EPMC2982111 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Dudek Steven M SM Chiang Eddie T ET Camp Sara M SM Guo Yurong Y Zhao Jing J Brown Mary E ME Singleton Patrick A PA Wang Lichun L Desai Anjali A Arce Fernando T FT Lal Ratnesh R Van Eyk Jennifer E JE Imam Syed Z SZ Garcia Joe G N JG
Molecular biology of the cell 20100922 22
Nonmuscle myosin light chain kinase (nmMLCK), a multi-functional cytoskeletal protein critical to vascular homeostasis, is highly regulated by tyrosine phosphorylation. We identified multiple novel c-Abl-mediated nmMLCK phosphorylation sites by mass spectroscopy analysis (including Y231, Y464, Y556, Y846) and examined their influence on nmMLCK function and human lung endothelial cell (EC) barrier regulation. Tyrosine phosphorylation of nmMLCK increased kinase activity, reversed nmMLCK-mediated i ...[more]