Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC2982113 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Ma Xuefei X Jana Siddhartha S SS Conti Mary Anne MA Kawamoto Sachiyo S Claycomb William C WC Adelstein Robert S RS
Molecular biology of the cell 20100922 22
Ablation of nonmuscle myosin (NM) II-A or NM II-B results in mouse embryonic lethality. Here, we report the results of ablating NM II-C as well as NM II-C/II-B together in mice. NM II-C ablated mice survive to adulthood and show no obvious defects compared with wild-type littermates. However, ablation of NM II-C in mice expressing only 12% of wild-type amounts of NM II-B results in a marked increase in cardiac myocyte hypertrophy compared with the NM II-B hypomorphic mice alone. In addition, the ...[more]