A splice variant of ADAMTS13 is expressed in human hepatic stellate cells and cancerous tissues.
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ABSTRACT:
SUBMITTER: Shomron N
PROVIDER: S-EPMC2982681 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
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A splice variant of ADAMTS13 is expressed in human hepatic stellate cells and cancerous tissues.
Shomron Noam N Hamasaki-Katagiri Nobuko N Hunt Ryan R Hershko Klilah K Pommier Elie E Geetha S S Blaisdell Adam A Dobkin Alexandra A Marple Andrew A Roma Isabella I Newell Jordan J Allen Courtni C Friedman Scott S Kimchi-Sarfaty Chava C
Thrombosis and haemostasis 20100720 3
Although ADAMTS13, the von Willebrand factor (VWF)-cleaving protease, is expressed in a range of tissues, the physiological significance of tissue-specific ADAMTS13 alternative splicing isoforms have yet to be clarified. Screening a panel of human tissues and cell lines revealed a spliced ADAMTS13 transcript in hepatic stellate cells and a hepatoma cell line that retains the 25th intron. A nonsense codon within the intron truncates the protease, which gains 64 novel amino acids in lieu of both C ...[more]
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