A peptide antagonist of the TLR4-MD2 interaction.
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ABSTRACT:
SUBMITTER: Slivka PF
PROVIDER: S-EPMC2982775 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
A peptide antagonist of the TLR4-MD2 interaction.
Slivka Peter F PF Shridhar Mitesh M Lee Gui-in GI Sammond Deanne W DW Hutchinson Mark R MR Martinko Alexander J AJ Buchanan Madison M MM Sholar Page W PW Kearney Jeffrey J JJ Harrison Jacqueline A JA Watkins Linda R LR Yin Hang H
Chembiochem : a European journal of chemical biology 20090301 4
Toll-like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll-like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS-related diseases such as sepsis and chronic pain. We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signal ...[more]
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