Ontology highlight
ABSTRACT:
SUBMITTER: Figlerowicz M
PROVIDER: S-EPMC2982956 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Archives of virology 20100915 12
Accumulating evidence suggests that certain features of hepatitis C virus (HCV), especially its high genetic variability, might be responsible for the low efficiency of anti-HCV treatment. Here, we present a bioinformatic analysis of HCV-1a populations isolated from 23 children with chronic hepatitis C (CHC) subjected to interferon-ribavirin therapy. The structures of the viral quasispecies were established based on a 132-amino-acid sequence derived from E1/E2 protein, including hypervariable re ...[more]