Ontology highlight
ABSTRACT:
SUBMITTER: Mok YG
PROVIDER: S-EPMC2984145 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Mok Young Geun YG Uzawa Rie R Lee Jiyoon J Weiner Gregory M GM Eichman Brandt F BF Fischer Robert L RL Huh Jin Hoe JH
Proceedings of the National Academy of Sciences of the United States of America 20101025 45
DNA glycosylases initiate the base excision repair (BER) pathway by excising damaged, mismatched, or otherwise modified bases. Animals and plants independently evolved active BER-dependent DNA demethylation mechanisms important for epigenetic reprogramming. One such DNA demethylation mechanism is uniquely initiated in plants by DEMETER (DME)-class DNA glycosylases. Arabidopsis DME family glycosylases contain a conserved helix-hairpin-helix domain present in both prokaryotic and eukaryotic DNA gl ...[more]