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Joint influence of small-effect genetic variants on human longevity.

ABSTRACT: The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant. We show that this joint influence can be described by a relatively simple "genetic dose - phenotypic response" relationship.

SUBMITTER: Yashin AI

PROVIDER: S-EPMC2984609 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Joint influence of small-effect genetic variants on human longevity.

Yashin Anatoliy I AI Wu Deqing D Arbeev Konstantin G KG Ukraintseva Svetlana V SV

Aging 20100901 9

The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be ...[more]

PMID: 20834067

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Correction to: Effect of longevity genetic variants on the molecular aging rate.

Project description: Not available

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