Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC298694 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Yang W W Gao Y Q YQ Cui Q Q Ma J J Karplus M M
Proceedings of the National Academy of Sciences of the United States of America 20030127 3
F(1)F(o)-ATP synthase is the enzyme responsible for most of the ATP synthesis in living systems. The catalytic domain F(1) of the F(1)F(o) complex, F(1)-ATPase, has the ability to hydrolyze ATP. A fundamental problem in the development of a detailed mechanism for this enzyme is that it has not been possible to determine experimentally the relation between the ligand binding affinities measured in solution and the different conformations of the catalytic beta subunits (beta(TP), beta(DP), beta(E) ...[more]