Ontology highlight
ABSTRACT:
SUBMITTER: Mero IL
PROVIDER: S-EPMC2987240 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Mero Inger-Lise IL Lorentzen Aslaug R AR Ban Maria M Smestad Cathrine C Celius Elisabeth G EG Aarseth Jan H JH Myhr Kjell-Morten KM Link Jenny J Hillert Jan J Olsson Tomas T Kockum Ingrid I Masterman Thomas T Oturai Annette Bang AB Søndergaard Helle Bach HB Sellebjerg Finn F Saarela Janna J Kemppinen Anu A Elovaara Irina I Spurkland Anne A Dudbridge Frank F Lie Benedicte A BA Harbo Hanne F HF
European journal of human genetics : EJHG 20091104 4
A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. However, because of the low frequency of the minor allele (minor allele frequency=0.04), genome-wide significant association has been hard to establish. We genotyped 5429 Nordic MS cases and 6167 healthy controls for this TYK2 non-synonymous single-nucleotide polymorphism (ns-SNP), and combined the Nordic genotype data with raw genotypes from previous studies. ...[more]