Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis.
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ABSTRACT:
SUBMITTER: Hattori T
PROVIDER: S-EPMC2987761 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis.
Hattori Takeshi T Konno Satoshi S Takahashi Ayumu A Isada Akira A Shimizu Kaoruko K Shimizu Kenichi K Taniguchi Natsuko N Gao Peisong P Yamaguchi Etsuro E Hizawa Nobuyuki N Huang Shau-Ku SK Nishimura Masaharu M
BMC medical genetics 20101028
<h4>Background</h4>Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis.<h4>Methods</h4>Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 hea ...[more]
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