Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC2988594 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Xu Delin D Seghezzi Nicolas N Esnault Catherine C Virolle Marie-Joelle MJ
Applied and environmental microbiology 20101008 23
The overexpression of a regulatory gene of the TetR family (SCO3201) originating either from Streptomyces lividans or from Streptomyces coelicolor was shown to strongly repress antibiotic production (calcium-dependent antibiotic [CDA], undecylprodigiosin [RED], and actinorhodin [ACT]) of S. coelicolor and of the ppk mutant strain of S. lividans. Curiously, the overexpression of this gene also had a strong inhibitory effect on the sporulation process of S. coelicolor but not on that of S. lividan ...[more]