Ontology highlight
ABSTRACT:
SUBMITTER: Vinothkumar KR
PROVIDER: S-EPMC2989101 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Vinothkumar Kutti R KR Strisovsky Kvido K Andreeva Antonina A Christova Yonka Y Verhelst Steven S Freeman Matthew M
The EMBO journal 20101001 22
Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular signalling, parasitic invasion of host cells, and mitochondrial morphology. Their widespread biological significance and consequent medical potential provides a strong incentive to understand the mechanism of these unusual enzymes for identification of specific inhibitors. In this ...[more]