Posttranslational modification of mammalian AP endonuclease (APE1).
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ABSTRACT:
SUBMITTER: Busso CS
PROVIDER: S-EPMC2989845 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Posttranslational modification of mammalian AP endonuclease (APE1).
Busso Carlos S CS Lake Michael W MW Izumi Tadahide T
Cellular and molecular life sciences : CMLS 20100814 21
A key issue in studying mammalian DNA base excision repair is how its component proteins respond to a plethora of cell-signaling mediators invoked by DNA damage and stress-inducing agents such as reactive oxygen species, and how the actions of individual BER proteins are attributed to cell survival or apoptotic/necrotic death. This article reviews the past and recent progress on posttranslational modification (PTM) of mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1). ...[more]
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