Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.
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ABSTRACT:
SUBMITTER: Massoner P
PROVIDER: S-EPMC2990579 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
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Insulin-like growth factors and insulin control a multifunctional signalling network of significant importance in cancer.
Massoner P P Ladurner-Rennau M M Eder I E IE Klocker H H
British journal of cancer 20101005 10
Insulin-like growth factor (IGF) and insulin (INS) proteins regulate key cellular functions through a complex interacting multi-component molecular network, known as the IGF/INS axis. We describe how dynamic and multilayer interactions give rise to the multifunctional role of the IGF/INS axis. Furthermore, we summarise the importance of the regulatory IGF/INS network in cancer, and discuss the possibilities and limitations of therapies targeting the IGF/INS axis with reference to ongoing clinica ...[more]
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