Ontology highlight
ABSTRACT:
SUBMITTER: Hu F
PROVIDER: S-EPMC2990962 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Hu Fenghua F Padukkavidana Thihan T Vægter Christian B CB Brady Owen A OA Zheng Yanqiu Y Mackenzie Ian R IR Feldman Howard H HH Nykjaer Anders A Strittmatter Stephen M SM
Neuron 20101101 4
<h4>Video abstract</h4>The most common inherited form of Frontotemporal Lobar Degeneration (FTLD) known stems from Progranulin (GRN) mutation and exhibits TDP-43 plus ubiquitin aggregates. Despite the causative role of GRN haploinsufficiency in FTLD-TDP, the neurobiology of this secreted glycoprotein is unclear. Here, we examined PGRN binding to the cell surface. PGRN binds to cortical neurons via its C terminus, and unbiased expression cloning identifies Sortilin (Sort1) as a binding site. Sort ...[more]