Ontology highlight
ABSTRACT:
SUBMITTER: Moyes DL
PROVIDER: S-EPMC2991069 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Moyes David L DL Runglall Manohursingh M Murciano Celia C Shen Chengguo C Nayar Deepa D Thavaraj Selvam S Kohli Arinder A Islam Ayesha A Mora-Montes Hector H Challacombe Stephen J SJ Naglik Julian R JR
Cell host & microbe 20100901 3
Discriminating between commensal and pathogenic states of opportunistic pathogens is critical for host mucosal defense and homeostasis. The opportunistic human fungal pathogen Candida albicans is also a constituent of the normal oral flora and grows either as yeasts or hyphae. We demonstrate that oral epithelial cells orchestrate an innate response to C. albicans via NF-κB and a biphasic MAPK response. Activation of NF-κB and the first MAPK phase, constituting c-Jun activation, is independent of ...[more]