Ontology highlight
ABSTRACT:
SUBMITTER: Gatzeva-Topalova PZ
PROVIDER: S-EPMC2991101 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20101101 11
Folding and insertion of β-barrel outer membrane proteins (OMPs) is essential for Gram-negative bacteria. This process is mediated by the multiprotein complex BAM, composed of the essential β-barrel OMP BamA and four lipoproteins (BamBCDE). The periplasmic domain of BamA is key for its function and contains five "polypeptide transport-associated" (POTRA) repeats. Here, we report the crystal structure of the POTRA4-5 tandem, containing the essential for BAM complex formation and cell viability PO ...[more]