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Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism.


ABSTRACT:

Objective

We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.

Research design and methods

A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement.

Results

A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered.

Conclusions

Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.

SUBMITTER: Kim MK 

PROVIDER: S-EPMC2992186 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Publications

Effects of thyroid hormone on A1C and glycated albumin levels in nondiabetic subjects with overt hypothyroidism.

Kim Mee Kyoung MK   Kwon Hyuk Sang HS   Baek Ki-Hyun KH   Lee Je Hoon JH   Park Woo Chan WC   Sohn Hyung Sun HS   Lee Kwang-Woo KW   Song Ki-Ho KH  

Diabetes care 20100907 12


<h4>Objective</h4>We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.<h4>Research design and methods</h4>A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement  ...[more]

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