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ABSTRACT: Objective
We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.Research design and methods
A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement.Results
A1C levels were higher in patients with hypothyroidism compared with control subjects. A1C levels were decreased by thyroid hormone replacement. Thyroid hormone replacement increased serum erythropoietin, reticulocyte count, and mean corpuscular hemoglobin (MCH). The change in A1C level was significantly correlated with the change in reticulocyte count or MCH. Thyroid hormone replacement decreased serum levels of albumin and GA. However, FBG and 1,5-anhydroglucitol levels were not altered.Conclusions
Levels of A1C and GA are spuriously high in nondiabetic patients with overt hypothyroidism.
SUBMITTER: Kim MK
PROVIDER: S-EPMC2992186 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Kim Mee Kyoung MK Kwon Hyuk Sang HS Baek Ki-Hyun KH Lee Je Hoon JH Park Woo Chan WC Sohn Hyung Sun HS Lee Kwang-Woo KW Song Ki-Ho KH
Diabetes care 20100907 12
<h4>Objective</h4>We aimed to determine the effects of thyroid hormone on A1C and glycated albumin (GA) in nondiabetic patients with overt hypothyroidism.<h4>Research design and methods</h4>A1C levels were measured in 45 nondiabetic patients with overt hypothyroidism and 180 euthyroid control subjects. A1C, GA, fasting blood glucose (FBG), 1,5-anhydroglucitol, and erythrocyte indexes were determined in 30 nondiabetic patients with overt hypothyroidism before and after thyroid hormone replacement ...[more]