Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC2992366 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Chen Yongwen Y Qiao Shengjun S Tuckermann Jan J Okret Sam S Jondal Mikael M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100826 12
Androgens contribute to the involution process of the aging thymus gland. However, molecular mechanisms behind this effect remain largely unknown. We have investigated the influence of testosterone on the ectopic synthesis of glucocorticoids (GCs) in thymocytes, an activity recently shown by us to be important for the homeostatic regulation of these cells. Castration, which leads to a strong increase in thymus tissue and function, was associated with a reduced GC release from thymocytes caused b ...[more]