Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery.

ABSTRACT:

Objective

To test the hypothesis that perioperative statin use reduces acute kidney injury (AKI) after cardiac surgery.

Design

A retrospective analysis of prospectively collected data from an ongoing clinical trial.

Setting

A quaternary-care university hospital.

Participants

Three hundred twenty-four adult elective cardiac surgery patients.

Interventions

None.

Measurements and main results

The authors assessed the association of preoperative statin use, early postoperative statin use, and acute statin withdrawal with the incidence of AKI. Early postoperative statin use was defined as statin treatment within the first postoperative day. Statin withdrawal was defined as the discontinuation of preoperative statin treatment before surgery until at lea

SUBMITTER: Billings FT 

PROVIDER: S-EPMC2992577 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature