Ontology highlight
ABSTRACT:
SUBMITTER: Bronson PG
PROVIDER: S-EPMC2992879 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Bronson P G PG Ramsay P P PP Seldin M F MF Gregersen P K PK Criswell L A LA Barcellos L F LF
Genes and immunity 20100311 6
CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis. Subsequently, associations between CLEC16A and rheumatoid arthritis (RA), Addison's disease and Crohn's disease have been reported. A large comprehensive and independent investigation of CLEC16A variation in RA was pursued. This study tested 251 CLEC16A single-nucleotide polymorphisms in 2542 RA cases (85% anti-cyclic citrullinated peptide (anti-CCP) positive) and 22 ...[more]