Ontology highlight
ABSTRACT:
SUBMITTER: Mullaney BC
PROVIDER: S-EPMC2992884 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Mullaney Brendan C BC Blind Raymond D RD Lemieux George A GA Perez Carissa L CL Elle Ida C IC Faergeman Nils J NJ Van Gilst Marc R MR Ingraham Holly A HA Ashrafi Kaveh K
Cell metabolism 20101001 4
Acyl-CoA synthases are important for lipid synthesis and breakdown, generation of signaling molecules, and lipid modification of proteins, highlighting the challenge of understanding metabolic pathways within intact organisms. From a C. elegans mutagenesis screen, we found that loss of ACS-3, a long-chain acyl-CoA synthase, causes enhanced intestinal lipid uptake, de novo fat synthesis, and accumulation of enlarged, neutral lipid-rich intestinal depots. Here, we show that ACS-3 functions in seam ...[more]