MAPK induces AQP1 expression in astrocytes following injury.
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ABSTRACT:
SUBMITTER: McCoy E
PROVIDER: S-EPMC2992951 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
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MAPK induces AQP1 expression in astrocytes following injury.
McCoy Eric E Sontheimer Harald H
Glia 20100101 2
Aquaporin-4 (AQP4) is the principle water channel and the primary route for water transport across astrocytic membranes. AQP4 co-localizes with Kir4.1 channels at astrocytic endfeet, and it has been suggested that these channels cooperate in K(+) and water homeostasis. In response to injury, two additional aquaporins, AQP1 and AQP9, can be detected in astrocytes, yet neither is found in cultured astrocytes, and therefore their contribution to astrocyte water uptake and biology is poorly investig ...[more]
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