Ontology highlight
ABSTRACT:
SUBMITTER: Blasius AL
PROVIDER: S-EPMC2993408 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Blasius Amanda L AL Arnold Carrie N CN Georgel Philippe P Rutschmann Sophie S Xia Yu Y Lin Pei P Ross Charles C Li Xiaohong X Smart Nora G NG Beutler Bruce B
Proceedings of the National Academy of Sciences of the United States of America 20101102 46
Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are required for pDCs, as well as other cell types, to sense viral nucleic acids, but the mechanism by which signaling through these shared receptors results in the prodigious production of type I IFN by pDCs is not understood. We designed a genetic screen to identify proteins required for ...[more]