Ontology highlight
ABSTRACT:
SUBMITTER: de Latour RP
PROVIDER: S-EPMC2993623 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
de Latour Regis Peffault RP Visconte Valeria V Takaku Tomoiku T Wu Colin C Erie Andrew J AJ Sarcon Annahita K AK Desierto Marie J MJ Scheinberg Phillip P Keyvanfar Keyvan K Nunez Olga O Chen Jichun J Young Neal S NS
Blood 20100823 20
T helper type 17 (Th17) cells have been characterized based on production of interleukin-17 (IL-17) and association with autoimmune diseases. We studied the role of Th17 cells in aplastic anemia (AA) by isolating Th17 cells from patients blood (n = 41) and bone marrow (BM) mononuclear cells (n = 7). The frequency and total number of CD3(+)CD4(+)IL-17-producing T cells were increased in AA patients at presentation compared with healthy controls (P = .0007 and .02, respectively) and correlated wit ...[more]