Ontology highlight
ABSTRACT:
SUBMITTER: Geoffroy MC
PROVIDER: S-EPMC2993750 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Geoffroy Marie-Claude MC Jaffray Ellis G EG Walker Katherine J KJ Hay Ronald T RT
Molecular biology of the cell 20101013 23
In acute promyelocytic leukemia (APL), the promyelocytic leukemia (PML) protein is fused to the retinoic acid receptor alpha (RAR). Arsenic is an effective treatment for this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RAR fusion protein. Here we analyze the nuclear trafficking dynamics of PML and its SUMO-dependent ubiquitin E3 ligase, RNF4 in response to arsenic. After administration of arsenic, PML immediately transits into nuclear bodies where i ...[more]