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Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria.

ABSTRACT: The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT(2B) receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays.

SUBMITTER: Lin Z

PROVIDER: S-EPMC2993768 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature

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Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria.

Lin Zhenjian Z Antemano Rowena R RR Hughen Ronald W RW Tianero Ma Diarey B MD Peraud Olivier O Haygood Margo G MG Concepcion Gisela P GP Olivera Baldomero M BM Light Alan A Schmidt Eric W EW

Journal of natural products 20101028 11

The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind ...[more]

PMID: 21028889

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2020-06-17 | MSV000085600 | MassIVE

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