Ontology highlight
ABSTRACT:
SUBMITTER: Soares JB
PROVIDER: S-EPMC2994611 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Hepatology international 20101021 4
Toll-like receptor 4 (TLR4) is a pattern recognition receptor that functions as lipopolysaccharide (LPS) sensor and whose activation results in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines. TLR4 is expressed in several cells of healthy liver. Despite the constant confrontation of hepatic TLR4 with gut-derived LPS, the normal liver does not show signs of inflammation due to its low expression of TLR4 and ability to modulate TLR4 signaling. Nevertheless, ther ...[more]