The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases.
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ABSTRACT:
SUBMITTER: Soares JB
PROVIDER: S-EPMC2994611 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
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The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases.
Soares João-Bruno JB Pimentel-Nunes Pedro P Roncon-Albuquerque Roberto R Leite-Moreira Adelino A
Hepatology international 20101021 4
Toll-like receptor 4 (TLR4) is a pattern recognition receptor that functions as lipopolysaccharide (LPS) sensor and whose activation results in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines. TLR4 is expressed in several cells of healthy liver. Despite the constant confrontation of hepatic TLR4 with gut-derived LPS, the normal liver does not show signs of inflammation due to its low expression of TLR4 and ability to modulate TLR4 signaling. Nevertheless, ther ...[more]
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